Kilburn is an area of north London, which is divided between three London Boroughs, London Borough of Brent, the London Borough of Camden, and small part in Westminster. The main thoroughfare running northwest-southeast is Kilburn High Road, part of the modern A5 road which forms the boundary between the boroughs of Brent and Camden. The road dates back to pre-Roman times and is part of the Roman road known as Watling Street. The town of Kilburn has its origins in a 12th-century priory on the banks of the Kilburn Brook. Kilburn today is a busy London district which used to be strongly associated with its Irish population. However, it has become very multicultural as of late.

Kilburn High Road is the main road in Kilburn. It follows a part of the line of the Roman Iter II route which later took the Anglo-Saxon name Watling Street. This was based on an earlier Celtic route from Verlamion to Durovernum Cantiacorum, modern day St Albans and Canterbury.

Running roughly North to South, it forms the boundary between the London boroughs of Camden (to the east) and Brent (to the west). It is a section of the Edgware Road (which is in turn part of Watling Street), between Shoot Up Hill and Maida Vale.

There are four railway stations on the Kilburn High Road: Kilburn tube station (Jubilee Line) at its northern end, then Brondesbury station (London Overground), shortly south of this. Approximately 1.25km further south is Kilburn High Road station (also London Overground, on the Watford DC Line). There is also Kilburn Park tube station, on the Bakerloo Line, which is just off the High Road and very close to the High Road station.

The green space of Kilburn Grange Park is located to the east side of Kilburn High Road.